Juan dela Cruz (Coco Martin) is the son of the mortal, Amelia (Mylene Dizon), and is is the latest successor to a line of tagapagbantay. His mother died giving birth to him, leaving the child in the care of Father Cito (Jaime Fabregas), the town's curé. Unbeknownst to Juan, he also has aswang blood from his demon father, Samuel (Albert Martinez); should the aswang know of this fact, they will force him to join their ranks , Javier The Ultimate Aswang Will Do Anything To Acquire The Earth But Juan Will Stop Him From His Evil Plans.